This comprehensive collection of essays provides a full account of the complexities of sex and gender as they relate to HIV/AIDS, in Ghana specifically and in Africa more generally. They offer perspectives from various disciplines and fields of study including anthropology, demography, history, literature, public health and sociology. The contributions stress the urgency of the pandemic and its threat to the existence of the African State. They further illustrate how aspects such as gender roles, social transformation, poverty, mobility, communication, changing cultural norms, cultural anxieties and exploitation are all interwoven in this multifaceted disease, and its various ramifications.