Abstract: A college textbook for students of medicine and other health sciences presents a progressive approach to the fundamental aspects of immunology and its practice. Twenty-nine topics by authorities in specific areas of immunology are organized into 3 major sections. The first section is devoted to fundamental principles, emphasizing recent findings on cellular interactions and genetic regulation. The second section consists of 13 topics on clinical applications of immunology (e.g., relative to bacteria, mycotic, viral, and parasitic diseases; transplantation immunology; blood groups; autoimmune diseases; antigens). The final section addressed several of the many practical applications of immunology in medical diagnosis and treatment (e.g., immunoassays; immunofluorescence; immunoelectonmicroscopy). (wz).